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1

Organs-on-chips at the frontiers of drug discovery

Esch, Eric W., Bahinski, Anthony, Huh, Dongeun

Journal:

Nature Reviews Drug Discovery

Year:

2015

Language:

english

File:

PDF, 546 KB

english, 2015

2

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

Benam, Kambez H, Villenave, Remi, Lucchesi, Carolina, Varone, Antonio, Hubeau, Cedric, Lee, Hyun-Hee, Alves, Stephen E, Salmon, Michael, Ferrante, Thomas C, Weaver, James C, Bahinski, Anthony, Hamilto

Journal:

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

3

Voltage dependence of transient and steady-state Na/K pump currents in myocytes

David C. Gadsby, Masakazu Nakao, Anthony Bahinski

Journal:

Molecular and Cellular Biochemistry

Year:

1989

Language:

english

File:

PDF, 460 KB

english, 1989

4

Alteration of channel characteristics by exchange of pore-forming regions between two structurally related Ca2+Channels

Atsuko Yatani, Anthony Bahinski, Minoru Wakamori, Shaoqing Tang, Yasuo Mori, Tsutomu Kobayashi, Arnold Schwartz

Journal:

Molecular and Cellular Biochemistry

Year:

1994

Language:

english

File:

PDF, 793 KB

english, 1994

5

Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes

Bahinski, Anthony, Nairn, Angus C., Greengard, Paul, Gadsby, David C.

Journal:

Year:

1989

File:

PDF, 428 KB

1989

6

Charged amino acids near the pore entrance influence ion-conduction of a human L-type cardiac calcium channel

Anthony Bahinski, Atsuko Yatani, Gabor Mikala, Shaoqing Tang, Satoshi Yamamoto, Arnold Schwartz

Journal:

Molecular and Cellular Biochemistry

Year:

1997

File:

PDF, 591 KB

1997

7

Effect of compound plate composition on measurement of hERG current IC50 using PatchXpress

Zun-Li Mo, Tracy Faxel, Young-Sun Yang, Robert Gallavan, Dean Messing, Anthony Bahinski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 1.44 MB

english, 2009

8

A mini-microscope for in situ monitoring of cells

Kim, Sang Bok, Koo, Kyo-in, Bae, Hojae, Dokmeci, Mehmet R., Hamilton, Geraldine A., Bahinski, Anthony, Kim, Sun Min, Ingber, Donald E., Khademhosseini, Ali

Journal:

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

9

Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore

Gabor Mikala, Anthony Bahinski, Atsuko Yatani, Shaoqing Tang, Arnold Schwartz

Journal:

Year:

1993

Language:

english

File:

PDF, 593 KB

english, 1993

10

Voltage dependence of transient and steady currents generated by the Na/K pump in cardiac cells

D.C. Gadsby, M. Nakao, A. Bahinski

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1990

Language:

english

File:

PDF, 99 KB

english, 1990

11

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents

Todd E. Haim, Wei Wang, Thomas P. Flagg, Michael A. Tones, Anthony Bahinski, Randal E. Numann, Colin G. Nichols, Jeanne M. Nerbonne

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

12

Voltage dependence of transient and steady-state Na/K pump currents in myocytes

David C. Gadsby, Masakazu Nakao, Anthony Bahinski

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1988

Language:

english

File:

PDF, 98 KB

english, 1988

13

Immediate early response of mouse atrial cardiac myocyte line HL-1 to hypertrophic stimuli

Qi Zhang, Jeff Demuth, Mike Murawsky, Anthony Bahinski, Richard Kawamoto, Claus-Jens Doersen

Journal:

Journal of Cardiac Failure

Year:

1999

Language:

english

File:

PDF, 147 KB

english, 1999

14

Clear castable polyurethane elastomer for fabrication of microfluidic devices

Domansky, Karel, Leslie, Daniel C., McKinney, James, Fraser, Jacob P., Sliz, Josiah D., Hamkins-Indik, Tiama, Hamilton, Geraldine A., Bahinski, Anthony, Ingber, Donald E.

Journal:

Year:

2013

Language:

english

File:

PDF, 967 KB

english, 2013

15

Microfabrication of human organs-on-chips

Huh, Dongeun, Kim, Hyun Jung, Fraser, Jacob P, Shea, Daniel E, Khan, Mohammed, Bahinski, Anthony, Hamilton, Geraldine A, Ingber, Donald E

Journal:

Nature Protocols

Year:

2013

Language:

english

File:

PDF, 2.63 MB

english, 2013

16

Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action

Tang, Shaoqing, Yatan, Atsuko, Bahinski, Anthony, Mori, Yasuo, Schwartz, Arnold

Journal:

Year:

1993

Language:

english

File:

PDF, 931 KB

english, 1993

17

Potassium Translocation by the Na+/K+Pump is Voltage Insensitive

Anthony Bahinski, Masakazu Nakao and David C. Gadsby

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 993 KB

english, 1988

18

HL-1 Cells: A Cardiac Muscle Cell Line that Contracts and Retains Phenotypic Characteristics of the Adult Cardiomyocyte

William C. Claycomb, Nicholas A. Lanson, Beverly S. Stallworth, Daniel B. Egeland, Joseph B. Delcarpio, Anthony Bahinski and Nicholas J. Izzo

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.76 MB

english, 1998

19

Evaluation of the Rubidium Efflux Assay for Preclinical Identification of hERG Blockade

Chaudhary, Khuram W., O'Neal, Janet M., Mo, Zun-Li, Fermini, Bernard, Gallavan, Robert H., Bahinski, Anthony

Journal:

Assay and Drug Development Technologies

Year:

2006

Language:

english

File:

PDF, 221 KB

english, 2006

20

Single amino acid substitutions within the ion permeation pathway alter single-channel conductance of the human L-type cardiac Ca2+ channel

Yatani, A., Bahinski, A., Mikala, G., Yamamoto, S., Schwartz, A.

Journal:

Circulation Research

Year:

1994

Language:

english

File:

PDF, 1.98 MB

english, 1994

21

Block of transient outward-type cloned cardiac K+ channel currents by quinidine

Yatani, A., Wakamori, M., Mikala, G., Bahinski, A.

Journal:

Circulation Research

Year:

1993

Language:

english

File:

PDF, 1.68 MB

english, 1993

22

Ca2+-Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy

Flagg, T. P., Cazorla, O., Remedi, M. S., Haim, T. E., Tones, M. A., Bahinski, A., Numann, R. E., Kovacs, A., Schaffer, J. E., Nichols, C. G., Nerbonne, J. M.

Journal:

Circulation Research

Year:

2008

Language:

english

File:

PDF, 574 KB

english, 2008

23

Synchronous occurrence of spontaneous localized calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential

Capogrossi, M. C., Houser, S. R., Bahinski, A., Lakatta, E. G.

Journal:

Circulation Research

Year:

1987

Language:

english

File:

PDF, 1.44 MB

english, 1987

24

The Promise and Potential of “Organs-on-Chips” as Preclinical Models

Bahinski, Anthony, Horland, Reyk, Huh, Dan, Mummery, Christine, Tagle, Danilo A., MacGill, Tracy

Journal:

Applied In Vitro Toxicology

Year:

2015

Language:

english

File:

PDF, 156 KB

english, 2015

25

Modeling hematopoiesis and responses to radiation countermeasures in a bone marrow-on-a-chip

Torisawa, Yu-suke, Mammoto, Tadanori, Jiang, Elisabeth, Jiang, Amanda, Mammoto, Akiko, Watters, Alexander L, Bahinski, Anthony, Ingber, Donald

Journal:

Tissue Engineering Part C Methods

Year:

2016

Language:

english

File:

PDF, 707 KB

english, 2016

26

Potassium translocation by the Na+/K+ pump is voltage insensitive.

Bahinski, A., Nakao, M., Gadsby, D. C.

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 944 KB

english, 1988

27

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

Benam, Kambez H., Novak, Richard, Nawroth, Janna, Hirano-Kobayashi, Mariko, Ferrante, Thomas C., Choe, Youngjae, Prantil-Baun, Rachelle, Weaver, James C., Bahinski, Anthony, Parker, Kevin K., Ingber,

Journal:

Year:

2016

Language:

english

File:

PDF, 3.15 MB

english, 2016

28

Human organs-on-chips

Journal:

Toxicology Letters

Year:

2016

Language:

english

File:

PDF, 47 KB

english, 2016

29

HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., Izzo, N. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 516 KB

english, 1998

30

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Kim, Hyun Jung, Lee, Jaewon, Choi, Jin-Ha, Bahinski, Anthony, Ingber, Donald E.

Journal:

Journal of Visualized Experiments

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

31

Using Multivariate Analysis to Score Acute CNS Toxicity in the Rat Cortical Neuron MEA Assay

Cato, Matthew, Gehman, Andrew, Burgert, Mark, Bahinski, Anthony, Chaudhary, Khuram

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 49 KB

english, 2017

32

Combined Cardiovascular, Respiratory, and Neurobehavioral Telemetry Model in the Conscious Rat: A Novel Approach to Study the Acute Physiological Effects of Caffeine and Chlorpromazine Following Oral Administration

Payseur, Jason, Wu, Xuejun, Bahinski, Anthony, Rossman, Eric

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 51 KB

english, 2017

33

Passive membrane properties of isolated feline ventricular myocytes

Houser, S. R., Bahinski, A., Silver, L. H.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1985

Language:

english

File:

PDF, 2.34 MB

english, 1985

34

Hypertrophy without contractile dysfunction after reversal of pressure overload in the cat

Wisenbaugh, T., Allen, P., Cooper, G., O'Connor, W. N., Mezaros, L., Streter, F., Bahinski, A., Houser, S., Spann, J. F.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1984

Language:

english

File:

PDF, 2.23 MB

english, 1984

35

Using fast Fourier transform to assess respiratory rate

Wu, XueJun, Payseur, Jason, Bayrak, Konuralp, Turner, Sandra, Bahinski, Anthony, Rossman, Eric I.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 41 KB

english, 2018

36

LO27: Improving emergency department management of acute opioid withdrawal

Klaiman, M. Z., Bahinski, K., Costello, L., Dell, E., McGowan, M., Medcalf, K., Phillips, S., Sylvestre, A., Vaillancourt, D., Cheng, A. H Y.

Journal:

Year:

2018

Language:

english

File:

PDF, 113 KB

english, 2018

37

LO27: Improving emergency department management of acute opioid withdrawal

Klaiman, M. Z., Bahinski, K., Costello, L., Dell, E., McGowan, M., Medcalf, K., Phillips, S., Sylvestre, A., Vaillancourt, D., Cheng, A. H Y.

Journal:

Year:

2018

File:

PDF, 113 KB

2018

38

Simultaneous measurement of contraction, voltage and calcium in HIPSC-CMS for the detection of inotropic effects under blinded conditions

de Korte, Tessa, van Meer, Berend, Garcia, Ana Krotenberg, Tertoolen, Leon, Clements, Peter J., Bahinski, Anthony, Rossman, Eric I., Xu, Xiaoping, Turner, Samantha, Denning, Chris, Vlaming, Marijn, Br

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2019

Language:

english

File:

PDF, 182 KB

english, 2019

39

The effect of DMSO on the contraction and relaxation of isolated thoracic aorta of the CRL:WI(Han) rat

Payseur, Jason D., Wu, Xuejun, Turner, Sandra L., Bayrak, Konuralp, Bahinski, Anthony, Rossman, Eric I.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2019

File:

PDF, 181 KB

2019

40

In vitro methods for detecting drug-induced hERG trafficking deficiencies

Valentine, Patricia A., Bahinski, Anthony, Petrucci, Dana, Chaudhary, Khuram W., Wilk, Deidre Dalmas, Talecki, Lindsey J.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2019

File:

PDF, 190 KB

2019

41

Time for a Fully Integrated NonclinicalâClinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J,

Journal:

Clinical Pharmacology & Therapeutics

Year:

2020

File:

PDF, 12.19 MB

2020